Structure of PDB 2r6f Chain B

Receptor sequence

>2r6fB (length=879) Species: 272567 (Geobacillus stearothermophilus 10)

MDKIIVKGARAHNLKNIDVEIPRGKLVVLTGLSGSGKSSLAFDTIYAEGQ
RRYVESLSAYARQFLGQMEKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT
VTEIYDYLRLLFARIGRPICPTHGIEIQSQTIEQMVDRLLSYPERTKMQI
LDRIIIKDGIAARLADSLETALKLADKHACPYCGFSIGELEPRLFSFNSP
FGACPDCDGLGAKLEVDLDLVIPNDELTLKEHAIAPWEPQSSQYYPQLLE
AVCRHYGIPMDVPVKDLPKEQLDKILYGSGGEPIYFRYTNDFGQVREQYI
AFEGVIPNVERRYRETSSDYIREQMEKYMAEQPCPTCQGYRLKKESLAVL
VGGKHIGEVTAMSVTEALAFFDGLELTEKEAQIARLILREIRDRLGFLQN
VGLDYLTLSRSAGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQR
DNDRLIATLKSMRDLGNTLIVVEHDEDTMLAADYLIDIGPGAGIHGGEVV
AAGTPEEVMNDPNSLTGQYLSGKKFIPIPAERRRPDGRWLEVVGAREHNL
KNVSVKIPLGTFVAVTGVSGSGKSTLVNEVLYKALAQKLHRAKAKPGEHR
DIRGLEHLDKVIDIDQSPIGRTPRSNPATYTGVFDDIRDVFASTNEAKVR
GYKKGRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRE
TLEVTYKGKNIAEVLDMTVEDALDFFASIPKIKRKLETLYDVGLGYMKLG
QPATTLSGGEAQRVKLAAELHRRSNGRTLYILDEPTTGLHVDDIARLLDV
LHRLVDNGDTVLVIEHNLDVIKTADYIIDLGPEGGDRGGQIVAVGTPEEV
AEVKESHTGRYLKPILERDRARMQARYEA

3D structure

• PDB: 2r6f Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-Modulated Dimerization, UvrB Interaction, and DNA Binding.
• Chain: B
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	H12 G34 G36 K37 S38 S39 Q821 T825	H12 G34 G36 K37 S38 S39 Q751 T755
BS02	ADP	B	R480 H618 N619 G640 S641 G642 K643 S644 T645	R410 H548 N549 G570 S571 G572 K573 S574 T575
BS03	ZN	B	C120 H123 C250 C253	C120 H123 C180 C183
BS04	ZN	B	C274 C277 C404 C407	C204 C207 C334 C337
BS05	ZN	B	C736 C739 C759 C762	C666 C669 C689 C692

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003824 catalytic activity
• GO:0004518 nuclease activity
• GO:0005524 ATP binding
• GO:0008270 zinc ion binding
• GO:0009381 excinuclease ABC activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006281 DNA repair
• GO:0006289 nucleotide-excision repair
• GO:0009432 SOS response

Cellular Component

• GO:0005737 cytoplasm
• GO:0009380 excinuclease repair complex

External links

• PDB: RCSB:2r6f, PDBe:2r6f, PDBj:2r6f
• PDBsum: 2r6f
• PubMed: 18158267
• UniProt: Q5KVB6