Structure of PDB 2r4b Chain B

Receptor sequence
>2r4bB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGET
VKIPVAIKILANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMP
HGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVL
VKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ
SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY
MVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD
3D structure
PDB2r4b 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D843 A845 R847 N848 D861 G880
Catalytic site (residue number reindexed from 1) D143 A145 R147 N148 D161 G180
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW7 B A749 K751 M772 V781 L783 L794 T796 M799 C803 L850 T860 D861 F862 A56 K58 M72 V81 L83 L94 T96 M99 C103 L150 T160 D161 F162
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2r4b, PDBe:2r4b, PDBj:2r4b
PDBsum2r4b
PubMed18287036
UniProtQ15303|ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4 (Gene Name=ERBB4)

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