Structure of PDB 2qzo Chain B

Receptor sequence
>2qzoB (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB2qzo Coupling of receptor conformation and ligand orientation determine graded activity.
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 E542 I53 K57 L67 V71 E75 D226 L227 E230
BS02 KN1 B E353 L387 M388 M421 G521 H524 E48 L82 M83 M116 G209 H212 BindingDB: IC50=1300nM
External links
PDB RCSB:2qzo, PDBe:2qzo, PDBj:2qzo
PDBsum2qzo
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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