Structure of PDB 2qyk Chain B

Receptor sequence
>2qykB (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
HMNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMI
FQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL
LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYND
ESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK
HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKP
LELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDY
IVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAI
3D structure
PDB2qyk Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NPV B Y371 M485 N533 I548 F552 M569 S580 Q581 F584 Y84 M198 N246 I261 F265 M282 S293 Q294 F297 MOAD: ic50=3.3uM
BindingDB: IC50=3300nM,EC50=20nM
BS02 ZN B H376 H412 D413 D530 H89 H125 D126 D243
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2qyk, PDBe:2qyk, PDBj:2qyk
PDBsum2qyk
PubMed17727341
UniProtP27815|PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (Gene Name=PDE4A)

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