Structure of PDB 2qxs Chain B

Receptor sequence
>2qxsB (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKR
VPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYLEEK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKCKNVVPSYDLLLEMLDAHR
3D structure
PDB2qxs Coupling of receptor conformation and ligand orientation determine graded activity.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAL B L346 T347 A350 D351 E353 W383 I424 H524 L525 V533 P535 L33 T34 A37 D38 E40 W70 I111 H202 L203 V211 P213 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:2qxs, PDBe:2qxs, PDBj:2qxs
PDBsum2qxs
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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