Structure of PDB 2qxm Chain B

Receptor sequence

>2qxmB (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]

LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLH

3D structure

PDB

2qxm NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 E380 D538 L539 E542	I53 K57 L67 E75 D230 L231 E234
BS02	PIQ	B	L349 A350 E353 L391 F404 M421	L44 A45 E48 L86 F99 M116

External links

PDB	RCSB:2qxm, PDBe:2qxm, PDBj:2qxm
PDBsum	2qxm
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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