Structure of PDB 2qtu Chain B

Receptor sequence
>2qtuB (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
LDALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKK
IPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRD
EGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKVYDLLLEMLNAHVL
3D structure
PDB2qtu Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies.
ChainB
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3AS B M295 L298 T299 E305 M336 L339 I373 I376 F377 H475 L476 M30 L33 T34 E40 M71 L74 I108 I111 F112 H203 L204 BindingDB: Ki=0.53nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2qtu, PDBe:2qtu, PDBj:2qtu
PDBsum2qtu
PubMed17804226
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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