Structure of PDB 2qqs Chain B

Receptor sequence
>2qqsB (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
ITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVS
QDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVV
KRDDVYTL
3D structure
PDB2qqs Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
ChainB
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide B N931 G935 S936 F937 D939 W967 N33 G37 S38 F39 D41 W69
External links
PDB RCSB:2qqs, PDBe:2qqs, PDBj:2qqs
PDBsum2qqs
PubMed18084306
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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