Structure of PDB 2qqe Chain B

Receptor sequence
>2qqeB (length=158) Species: 2336 (Thermotoga maritima) [Search protein sequence]
SGKLTVITGPMYSGKTTELLSFVEIYKLGKKKVAVFKPKVEAHVIERPEE
MRKYIEEDTRGVFIDEVQFFNPSLFEVVKDLLDRGIDVFCAGLDLTHKQN
PFETTALLLSLADTVIKKKAVCHRCGEYNATLTLKVAIDVGGQEKYIAVC
RDCYNTLK
3D structure
PDB2qqe Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C140 C143 C173 C176 C122 C125 C150 C153
BS02 THM B M12 E84 Q86 F87 L111 T114 H115 F120 T151 I161 D162 G164 Y169 M11 E66 Q68 F69 L93 T96 H97 F102 T133 I138 D139 G141 Y146
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0046104 thymidine metabolic process
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qqe, PDBe:2qqe, PDBj:2qqe
PDBsum2qqe
PubMed18073106
UniProtQ9WYN2|KITH_THEMA Thymidine kinase (Gene Name=tdk)

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