Structure of PDB 2qo3 Chain B

Receptor sequence
>2qo3B (length=873) Species: 1836 (Saccharopolyspora erythraea) [Search protein sequence]
ESDPIAIVSMACRLPGGVNTPQRLWELLREGGETLSGFPTDRGWDLARLH
HPDPDNPGTSYVDKGGFLDDAAGFDAEFFGVSPREAAAMDPQQRLLLETS
WELVENAGIDPHSLRGTATGVFLGVAKFGYGEDTADVEGYSVTGVAPAVA
SGRISYTMGLEGPSISVDTACSSSLVALHLAVESLRKGESSMAVVGGAAV
MATPGVFVDFSRQRALAADGRSKAFGAGADGFGFSEGVTLVLLERLSEAR
RNGHEVLAVVRGSALNQDGASNGLSAPSGPAQRRVIRQALESCGLEPGDV
DAVEAHGTGTALGDPIEANALLDTYGRDRDADRPLWLGSVKSNIGHTQAA
AGVTGLLKVVLALRNGELPATLHVEEPTPHVDWSSGGVALLAGNQPWRRG
ERTRRAAVSAFGISGTNAHVIVEEAPERTTAHDGRPVPLVVSARSTAALR
AQAAQIAELLERPDADLAGVGLGLATTRARHEHRAAVVASTREEAVRGLR
EIAAGAATADAVVEGVTEVDGRNVVFLFPGQGSQWAGMGAELLSSSPVFA
GKIRACDESMAPMQDWKVSDVLRQAPGAPGLDRVDVVQPVLFAVMVSLAE
LWRSYGVEPAAVVGHSQGEIAAAHVAGALTLEDAAKLVVGRSRLMRSLSG
EGGMAAVALGEAAVRERLRPWQDRLSVAAVNGPRSVVVSGEPGALRAFSE
DCAAEGIRVRDIDVDYASHSPQIERVREELLETTGDIAPRPARVTFHSTV
ESRSMDGTELDARYWYRNLRETVRFADAVTRLAESGYDAFIEVSPHPVVV
QAVEEAVEEADGAEDAVVVGSLHRDGGDLSAFLRSMATAHVSGVDIRWDV
ALPGAAPFALPTYPFQRKRYWLQ
3D structure
PDB2qo3 Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase
ChainB
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C202 H337 E348 K372 H377 F442 I444 Q566 S651 Q652 R676 H754 N803
Catalytic site (residue number reindexed from 1) C171 H306 E317 K341 H346 F411 I413 Q531 S616 Q617 R641 H719 N768
Enzyme Commision number 2.3.1.94: 6-deoxyerythronolide-B synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CER B C202 F263 H337 H377 I444 C171 F232 H306 H346 I413
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2qo3, PDBe:2qo3, PDBj:2qo3
PDBsum2qo3
PubMed17719492
UniProtQ03132|ERYA2_SACER 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4 (Gene Name=eryA)

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