Structure of PDB 2qnx Chain B

Receptor sequence
>2qnxB (length=332) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICIDSSDEWIYTRTGIKTR
RFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAP
MVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKL
SPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQD
IDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQI
DVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAEL
LTTGAAKPGDLALLIGYGAGLSYAAQVVRMPK
3D structure
PDB2qnx Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
ChainB
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.301: mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDT B I189 L207 H244 A246 N274 I197 L219 H256 A258 N287 PDBbind-CN: -logKd/Ki=5.62,IC50=2.4uM
BS02 MDX B N81 C112 L142 T145 I189 Q191 V205 S276 A306 N89 C120 L150 T153 I197 Q199 V217 S289 A319
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity
GO:0061990 beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0030497 fatty acid elongation
GO:0035336 long-chain fatty-acyl-CoA metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2qnx, PDBe:2qnx, PDBj:2qnx
PDBsum2qnx
PubMed18420147
UniProtP9WNG3|FABH_MYCTU Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (Gene Name=fabH)

[Back to BioLiP]