Structure of PDB 2ql6 Chain B

Receptor sequence
>2ql6B (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
KTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNG
FLQYDVLEALNMEKMMSAISCWMESARHIPILIIEGFLLFNYKPLDTIWN
RSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQDITW
EVVYLDGTKSEEDLFLQVYEDLIQELAKQ
3D structure
PDB2ql6 Crystal structure of human nicotinamide riboside kinase
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.173: nicotinate riboside kinase.
2.7.1.22: ribosylnicotinamide kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B N13 G15 K16 T17 T18 R128 N12 G14 K15 T16 T17 R115
BS02 TIZ B D36 F39 Y55 D56 F100 R129 Y134 Q135 D35 F38 Y54 D55 F87 R116 Y121 Q122
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0034317 nicotinate riboside kinase activity
GO:0046872 metal ion binding
GO:0050262 ribosylnicotinamide kinase activity
GO:0061769 ribosylnicotinate kinase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0016310 phosphorylation
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019674 NAD metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2ql6, PDBe:2ql6, PDBj:2ql6
PDBsum2ql6
PubMed17698003
UniProtQ9NWW6|NRK1_HUMAN Nicotinamide riboside kinase 1 (Gene Name=NMRK1)

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