Structure of PDB 2qkb Chain B

Receptor sequence
>2qkbB (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMGDFVVVYTDGCCSSNRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQR
AEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKTSA
GKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQS
3D structure
PDB2qkb Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B D145 C147 C148 N151 N182 E186 N210 M212 H260 G263 R278 D12 C14 C15 N18 N48 E52 N76 M78 H126 G129 R144
BS02 dna B N151 R179 T181 N182 Q183 F213 W221 W225 T232 S233 V238 I239 N240 N18 R45 T47 N48 Q49 F79 W87 W91 T98 S99 V104 I105 N106
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qkb, PDBe:2qkb, PDBj:2qkb
PDBsum2qkb
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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