Structure of PDB 2qh6 Chain B

Receptor sequence

>2qh6B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLSDLLLEMLDAH

3D structure

PDB

2qh6 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

2.7 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 D538 E542	I50 K54 D219 E223
BS02	ODE	B	L346 T347 E353 L384 M388 M421 I424 F425 H524 L525	L38 T39 E45 L76 M80 M113 I116 F117 H205 L206

External links

PDB	RCSB:2qh6, PDBe:2qh6, PDBj:2qh6
PDBsum	2qh6
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]