Structure of PDB 2qfx Chain B

Receptor sequence
>2qfxB (length=410) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRD
ATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIR
NILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPG
SLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKL
AIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHR
LIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPD
GKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNT
PALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAV
EKRLQKEIKS
3D structure
PDB2qfx Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D277 D281 D276 D280
BS02 NDP B T76 I77 R83 N97 L290 H311 G312 T313 V314 T315 R316 H317 N330 T75 I76 R82 N96 L289 H310 G311 T312 V313 T314 R315 H316 N329
BS03 AKG B T78 S95 N97 R101 R110 T77 S94 N96 R100 R109
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Cellular Component
External links
PDB RCSB:2qfx, PDBe:2qfx, PDBj:2qfx
PDBsum2qfx
PubMed18552125
UniProtP21954|IDHP_YEAST Isocitrate dehydrogenase [NADP], mitochondrial (Gene Name=IDP1)

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