Structure of PDB 2qfv Chain B

Receptor sequence
>2qfvB (length=408) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDAT
SDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNI
LGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSL
ELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAI
DKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLI
DDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK
TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPA
LCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEK
RLQKEIKS
3D structure
PDB2qfv Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B A75 T76 I77 T78 N97 H311 G312 T313 V314 R316 H317 T329 N330 A72 T73 I74 T75 N94 H308 G309 T310 V311 R313 H314 T326 N327
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qfv, PDBe:2qfv, PDBj:2qfv
PDBsum2qfv
PubMed18552125
UniProtP21954|IDHP_YEAST Isocitrate dehydrogenase [NADP], mitochondrial (Gene Name=IDP1)

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