Structure of PDB 2qby Chain B

Receptor sequence

>2qbyB (length=368) Species: 2287 (Saccharolobus solfataricus)

KNPKVFIDPLSVFKEIPFREDILRDAAIAIRYFVKNEVKFSNLFLGLTGT
GKTFVSKYIFNEIEEVKKEDEEYKDVKQAYVNCREVGGTPQAVLSSLAGK
LTGFSVPKHGINLGEYIDKIKNGTRNIRAIIYLDEVDTLVKRRGGDIVLY
QLLRSDANISVIMISNDINVRDYMEPRVLSSLGPSVIFKPYDAEQLKFIL
SKYAEYGLIKGTYDDEILSYIAAISAKEHGDARKAVNLLFRAAQLASGGG
IIRKEHVDKAIVDYEQERLIEAVKALPFHYKLALRSLIESEDVMSAHKMY
TDLCNKFKQKPLSYRRFSDIISELDMFGIVKIRIINRGRAGGVKKYALVE
DKEKVLRALNETFEDSIS

3D structure

• PDB: 2qby Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.
• Chain: B
• Resolution: 3.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	P123 H125 G126 M310 Y330 R331 I350 G354 R355 G357 V359 K360 K361	P107 H109 G110 M294 Y314 R315 I334 G338 R339 G341 V343 K344 K345
BS02	dna	B	T105 P106 Q107 G126 N128 L129 L328 S329 R332 N352 G354 R355	T89 P90 Q91 G110 N112 L113 L312 S313 R316 N336 G338 R339
BS03	ADP	B	F29 I32 P33 G65 G67 K68 T69 F70 Y207 I215 Y219 R249	F13 I16 P17 G49 G51 K52 T53 F54 Y191 I199 Y203 R233

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006260 DNA replication

External links

• PDB: RCSB:2qby, PDBe:2qby, PDBj:2qby
• PDBsum: 2qby
• PubMed: 17761879
• UniProt: Q97WM8|CDC63_SACS2 ORC1-type DNA replication protein 3 (Gene Name=cdc6-3)