Structure of PDB 2qbx Chain B

Receptor sequence
>2qbxB (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
EETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQ
NNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEAD
FDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPV
SRSGFYLAFQDYGGCMSLIAVRVFYR
3D structure
PDB2qbx Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E52 Q68 C70 N71 S101 V102 R103 D104 S107 R163 V164 M165 K166 M193 E25 Q41 C43 N44 S74 V75 R76 D77 S80 R136 V137 M138 K139 M166
External links
PDB RCSB:2qbx, PDBe:2qbx, PDBj:2qbx
PDBsum2qbx
PubMed17897949
UniProtP29323|EPHB2_HUMAN Ephrin type-B receptor 2 (Gene Name=EPHB2)

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