Structure of PDB 2qb5 Chain B

Receptor sequence
>2qb5B (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHMQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSR
PIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLD
PLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCTMRLLEKN
GLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLY
KVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPSSSVLTELDK
IEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAF
PGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL
3D structure
PDB2qb5 Integration of inositol phosphate signaling pathways via human ITPK1.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.134: inositol-tetrakisphosphate 1-kinase.
2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D281 D295 D282 D296
BS02 MN B D295 N297 D296 N298
BS03 ADP B R106 I155 K157 H167 M169 Q188 F190 I191 H193 S214 L215 S232 S236 I294 D295 R111 I157 K159 H169 M171 Q190 F192 I193 H195 S216 L217 S234 S238 I295 D296
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
Biological Process
GO:0032957 inositol trisphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2qb5, PDBe:2qb5, PDBj:2qb5
PDBsum2qb5
PubMed17616525
UniProtQ13572|ITPK1_HUMAN Inositol-tetrakisphosphate 1-kinase (Gene Name=ITPK1)

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