Structure of PDB 2qa8 Chain B

Receptor sequence

>2qa8B (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL

3D structure

PDB

2qa8 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 L372 V376 L379 E380 D538 L539 E542	I54 L68 V72 L75 E76 D224 L225 E228
BS02	GEN	B	E353 H524 L525	E49 H210 L211	BindingDB: IC50=395nM,EC50=240nM,Ki=370nM

External links

PDB	RCSB:2qa8, PDBe:2qa8, PDBj:2qa8
PDBsum	2qa8
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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