Structure of PDB 2qa6 Chain B

Receptor sequence
>2qa6B (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLH
3D structure
PDB2qa6 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 V376 L379 D538 L539 E542 I53 K57 V71 L74 D230 L231 E234
BS02 KN2 B L346 E353 H524 L525 L41 E48 H216 L217 BindingDB: IC50=48nM,EC50=298nM
External links
PDB RCSB:2qa6, PDBe:2qa6, PDBj:2qa6
PDBsum2qa6
PubMed18344977
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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