Structure of PDB 2q8z Chain B

Receptor sequence
>2q8zB (length=321) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKE
KYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALT
FKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYR
KFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSA
IFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMN
YIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNP
YPQKAAQMYYDQINAILKQNM
3D structure
PDB2q8z Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NUP B D141 I142 T145 D141 I142 T145 MOAD: Ki=2.1uM
PDBbind-CN: -logKd/Ki=5.68,Ki=2.1uM
BS02 NUP B D23 K102 N104 D136 K138 T194 T195 P264 Q269 N291 G293 R294 D23 K102 N104 D136 K138 T194 T195 P264 Q269 N291 G293 R294 MOAD: Ki=2.1uM
PDBbind-CN: -logKd/Ki=5.68,Ki=2.1uM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2q8z, PDBe:2q8z, PDBj:2q8z
PDBsum2q8z
PubMed18189347
UniProtQ8IJH3

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