Structure of PDB 2q5j Chain B

Receptor sequence
>2q5jB (length=530) Species: 192 (Azospirillum brasilense) [Search protein sequence]
MKLAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPA
VGFAADAAARYSSTLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAP
GTTEGNAGLLDTQFQVFKEITVAQARLDDPAKAPAEIARVLGAARAQSRP
VYLEIPRNMVNAEVEPVGDDPAWPVDRDALAACADEVLAAMRSATSPVLM
VCVEVRRYGLEAKVAELAQRLGVPVVTTFMGRGLLADAPTPPLGTYIGVA
GDAEITRLVEESDGLFLLGAILSDTNFAVSQRKIDLRKTIHAFDRAVTLG
YHTYADIPLAGLVDALLERLPPSDRTTRGKEPHAYPTGLQADGEPIAPMD
IARAVNDRVRAGQEPLLIAADMGDCLFTAMDMIDAGLMAPGYYAGMGFGV
PAGIGAQCVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNAS
WEMLRTFQPESAFNDLDDWRFADMAAGMGGDGVRVRTRAELKAALDKAFA
TRGRFQLIEAMIPRGVLSDTLARFVQGQKR
3D structure
PDB2q5j Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I22 G24 D25 F26 A27 E48 T71 R165 V257 N284 M380 A402 M404 D429 N456 S458 W459 M461 L462 F465 R522
Catalytic site (residue number reindexed from 1) I22 G24 D25 F26 A27 E48 T71 R157 V249 N276 M372 A394 M396 D421 N448 S450 W451 M453 L454 F457 R514
Enzyme Commision number 4.1.1.74: indolepyruvate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPW B P23 E48 P23 E48
BS02 MG B D429 N456 D421 N448
BS03 TPW B D382 A402 M404 G428 D429 G430 A431 N456 S458 W459 E460 M461 L462 D374 A394 M396 G420 D421 G422 A423 N448 S450 W451 E452 M453 L454
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0047434 indolepyruvate decarboxylase activity
Biological Process
GO:0009851 auxin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2q5j, PDBe:2q5j, PDBj:2q5j
PDBsum2q5j
PubMed17905741
UniProtP51852|DCIP_AZOBR Indole-3-pyruvate decarboxylase (Gene Name=ipdC)

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