Structure of PDB 2q5g Chain B

Receptor sequence
>2q5gB (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLKAFSKHIYNAYLKNFNMTKKKARSILTGAPFVIHDIETLWQAEKGLV
WEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHE
AIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKF
NALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQAN
HPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKT
3D structure
PDB2q5g Design of a partial PPARdelta agonist.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FA B M228 L255 F282 R284 C285 Q286 T288 T292 M329 L330 I333 L339 V341 V348 I363 I364 K367 H449 M20 L42 F58 R60 C61 Q62 T64 T68 M105 L106 I109 L115 V117 V124 I139 I140 K143 H225 BindingDB: EC50=130nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2q5g, PDBe:2q5g, PDBj:2q5g
PDBsum2q5g
PubMed17560785
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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