Structure of PDB 2q58 Chain B

Receptor sequence
>2q58B (length=329) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
YDYTDFINYYDKFKVIVYNVLKKLPVIEYYLNCIDYNVKKGKHIRGKILV
LISSLAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYI
VHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVL
GQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVS
SAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSF
EIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLV
KDITDDSLQKVFIHLIHQISELITNSRSN
3D structure
PDB2q58 Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
ChainB
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K2072 L2110 D2115 D2119 R2124 D2187 K2210 Y2250 N2254 D2255
Catalytic site (residue number reindexed from 1) K42 L78 D83 D87 R92 D155 K178 Y218 N222 D223
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D2115 D2119 D83 D87
BS02 MG B D2119 D2187 D87 D155
BS03 ZOL B D2115 R2124 K2210 T2211 Q2251 N2254 D83 R92 K178 T179 Q219 N222 BindingDB: IC50=30.1nM,Ki=0.050nM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2q58, PDBe:2q58, PDBj:2q58
PDBsum2q58
PubMed19101474
UniProtQ5CR09

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