Structure of PDB 2pzi Chain B

Receptor sequence
>2pziB (length=644) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GSHMLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRGASE
GWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNG
RPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGD
PVGYIVMEYVGGQSLKQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKP
ENIMLTEEQLKLIDLGAVSRINSFGLYGTPGFQAPEIVRTGPTVATDIYT
VGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQ
RFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAH
TEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGA
DFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAE
LLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVW
STNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVT
LLSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTN
HILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVR
3D structure
PDB2pzi Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D276 K278 N281 D293 T309
Catalytic site (residue number reindexed from 1) D197 K199 N202 D214 T229
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AXX B I157 V179 M232 E233 Y234 V235 I292 I82 V104 M157 E158 Y159 V160 I213 MOAD: ic50=3uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0006538 glutamate catabolic process
GO:0006543 glutamine catabolic process
GO:0016310 phosphorylation
GO:0030682 symbiont-mediated perturbation of host defenses
GO:0035556 intracellular signal transduction
GO:0042783 evasion of host immune response
GO:0043457 regulation of cellular respiration
GO:0046677 response to antibiotic
GO:0052027 symbiont-mediated perturbation of host signal transduction pathway
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pzi, PDBe:2pzi, PDBj:2pzi
PDBsum2pzi
PubMed17616581
UniProtP9WI73|PKNG_MYCTU Serine/threonine-protein kinase PknG (Gene Name=pknG)

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