Structure of PDB 2pzg Chain B

Receptor sequence
>2pzgB (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
LTTTEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLL
MMIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYR
SVIKACQLEEDISKFAEKDNIVLGITLSGGQRARISLARAVYKDADLYLL
DSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE
GSSYFYGTFSELQNL
3D structure
PDB2pzg Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T465 Q493 T47 Q75
BS02 ATP B W401 V440 T460 G461 G463 K464 T465 S466 Q493 W15 V22 T42 G43 G45 K46 T47 S48 Q75
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:2pzg, PDBe:2pzg, PDBj:2pzg
PDBsum2pzg
PubMed20150177
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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