Structure of PDB 2py3 Chain B

Receptor sequence
>2py3B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPKWEFPRDKLTLGKPLGGQVVMAEAVGIDKDKPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVGYASKGN
LREYLRARRPPGEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV
LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH
QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL
YMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN
3D structure
PDB2py3 A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644 R664
Catalytic site (residue number reindexed from 1) D144 A146 R148 N149 D162 R182
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N631 D644 N149 D162
BS02 ACP B G488 G493 A515 K517 Y566 A567 N571 L633 D644 G21 G22 A44 K46 Y95 A96 N100 L151 D162
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2py3, PDBe:2py3, PDBj:2py3
PDBsum2py3
PubMed17803937
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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