Structure of PDB 2pxj Chain B

Receptor sequence
>2pxjB (length=337) Species: 9606 (Homo sapiens) [Search protein sequence]
PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASY
DDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTP
RYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDL
VEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY
SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDK
VTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
KDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLP
3D structure
PDB2pxj Structural basis of the recognition of a methylated histone tail by JMJD2A
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1) G161 Y168 H179 E181 H267 S279
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B D135 I166 I168 E169 G170 Y175 N290 V313 K314 I315 S316 D126 I157 I159 E160 G161 Y166 N281 V304 K305 I306 S307
BS02 ZN B C234 H240 C306 C225 H231 C297
BS03 FE2 B H188 E190 H276 H179 E181 H267
BS04 OGA B Y132 F185 H188 S196 N198 W208 H276 Y123 F176 H179 S187 N189 W199 H267 BindingDB: IC50=250000nM
External links
PDB RCSB:2pxj, PDBe:2pxj, PDBj:2pxj
PDBsum2pxj
PubMed17567753
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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