Structure of PDB 2px5 Chain B

Receptor sequence
>2px5B (length=263) Species: 301478 (Murray valley encephalitis virus (strain MVE-1-51)) [Search protein sequence]
GRTLGEQWKEKLNAMGKEEFFSYRKEAILEVDRTEARRARREGNKVGGHP
VSRGTAKLRWLVERRFVQPIGKVVDLGCGRGGWSYYAATMKNVQEVRGYT
KGGPGHEEPMLMQSYGWNIVTMKSGVDVFYKPSEISDTLLCDIGESSPSA
EIEEQRTLRILEMVSDWLSRGPKEFCIKILCPYMPKVIEKLESLQRRFGG
GLVRVPLSRNSNHEMYWVSGASGNIVHAVNMTSQVLIGRMDKKIWKGPKY
EEDVNLGSGTRAV
3D structure
PDB2px5 Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B S56 G58 G81 G86 W87 K105 H110 E111 V130 D131 V132 F133 D146 S52 G54 G77 G82 W83 K101 H106 E107 V126 D127 V128 F129 D142
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2px5, PDBe:2px5, PDBj:2px5
PDBsum2px5
PubMed17622627
UniProtP05769|POLG_MVEV5 Genome polyprotein

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