Structure of PDB 2pv9 Chain B

Receptor sequence
>2pv9B (length=258) Species: 10090 (Mus musculus) [Search protein sequence]
IVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPW
DKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDI
ALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTT
NINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDA
CEGDAGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWI
QKVIDQFG
3D structure
PDB2pv9 Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
ChainB
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 A195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 A205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L40 H57 W60D R97 W148 T149A I174 D189 A190 E192 G193 A195 S214 W215 G216 L26 H43 W50 R93 W148 T150 I179 D199 A200 E202 G203 A205 S226 W227 G228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pv9, PDBe:2pv9, PDBj:2pv9
PDBsum2pv9
PubMed17606903
UniProtP19221|THRB_MOUSE Prothrombin (Gene Name=F2)

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