Structure of PDB 2pog Chain B

Receptor sequence
>2pogB (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVP
GFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQG
KSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLK
SLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSM
3D structure
PDB2pog Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.
ChainB
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WST B M343 E353 L384 L387 R394 F404 H524 M28 E38 L69 L72 R79 F89 H207 MOAD: Ki=0.29nM
BindingDB: Ki=0.35nM
External links
PDB RCSB:2pog, PDBe:2pog, PDBj:2pog
PDBsum2pog
PubMed17485205
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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