Structure of PDB 2pjl Chain B

Receptor sequence
>2pjlB (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
LEVLFQGPVNALVSHLLVVEPEKLYAMLPAVATLSDLFDREIVVTISWAK
SIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDE
EGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIED
AEAVEQLREALHEALLEYEAGRRRAGRLLLTLPLLRQTAGKVLAHFYGVK
LEGKVPMHKLFLEMLEAM
3D structure
PDB2pjl Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 047 B L324 E331 F382 G397 L398 F495 L500 L34 E41 F92 G107 L108 F196 L201 MOAD: ic50=190nM
BindingDB: IC50=190nM
External links
PDB RCSB:2pjl, PDBe:2pjl, PDBj:2pjl
PDBsum2pjl
PubMed17556356
UniProtP11474|ERR1_HUMAN Steroid hormone receptor ERR1 (Gene Name=ESRRA)

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