Structure of PDB 2pjb Chain B

Receptor sequence
>2pjbB (length=305) Species: 9823 (Sus scrofa) [Search protein sequence]
TGHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGK
PGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLD
FYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTT
GASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMIL
YPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGG
SDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNY
VLGHL
3D structure
PDB2pjb Structures of potent selective peptide mimetics bound to carboxypeptidase B.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H65 E68 R123 H193 E267
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H69 E72 H196 H65 E68 H193
BS02 983 B H69 E72 R127 N144 R145 T164 H196 S197 Y198 S207 Y248 P249 D255 E270 H65 E68 R123 N140 R141 T160 H193 S194 Y195 S204 Y245 P246 D252 E267 MOAD: ic50=19nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2pjb, PDBe:2pjb, PDBj:2pjb
PDBsum2pjb
PubMed18219114
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

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