Structure of PDB 2pj4 Chain B

Receptor sequence
>2pj4B (length=304) Species: 9823 (Sus scrofa) [Search protein sequence]
GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKP
GPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDF
YVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTG
ASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILY
PYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGS
DDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYV
LGHL
3D structure
PDB2pj4 Structures of potent selective peptide mimetics bound to carboxypeptidase B.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H64 E67 R122 H192 E266
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H69 E72 H196 H64 E67 H192
BS02 414 B H69 R71 E72 R127 N144 R145 T164 H196 Y198 L203 S207 I247 Y248 D255 E270 H64 R66 E67 R122 N139 R140 T159 H192 Y194 L199 S203 I243 Y244 D251 E266 MOAD: ic50=13nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2pj4, PDBe:2pj4, PDBj:2pj4
PDBsum2pj4
PubMed18219114
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

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