Structure of PDB 2pbj Chain B

Receptor sequence
>2pbjB (length=274) Species: 9541 (Macaca fascicularis) [Search protein sequence]
LQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVLRAEIKFSSYRKVP
ILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNDQG
KEVTEFGNKYWLMLNEKEAQQVYSGKEARTEEMKWRQWADDWLVHLISPN
VYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRL
QDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDA
FDDLMQHTHIQPWYLRVERAITEA
3D structure
PDB2pbj PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y107 C110 F112 C113
Catalytic site (residue number reindexed from 1) Y8 C11 F13 C14
Enzyme Commision number 5.3.99.3: prostaglandin-E synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B Y107 T109 C110 P111 F112 P134 V243 H244 Y8 T10 C11 P12 F13 P35 V144 H145
BS02 GSH B Y107 F112 K147 V148 D164 S165 Y8 F13 K48 V49 D65 S66
Gene Ontology
Molecular Function
GO:0050220 prostaglandin-E synthase activity

View graph for
Molecular Function
External links
PDB RCSB:2pbj, PDBe:2pbj, PDBj:2pbj
PDBsum2pbj
PubMed17585783
UniProtQ9N0A4|PGES2_MACFA Prostaglandin E synthase 2 (Gene Name=PTGES2)

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