Structure of PDB 2p6g Chain B

Receptor sequence
>2p6gB (length=435) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKAKKLENLLKLLQLNNHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISD
KPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFF
NWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINF
LCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYT
HRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDID
QVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPD
GKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKAT
KALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFL
NFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
3D structure
PDB2p6g Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N149 F150 L151 T185 L435
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA B H38 F40 W41 Y103 I168 N169 L171 V173 R178 S179 R181 T183 I187 T191 W200 H201 A202 Y204 I208 L210 F425 H18 F20 W21 Y83 I148 N149 L151 V153 R158 S159 R161 T163 I167 T171 W180 H181 A182 Y184 I188 L190 F405
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p6g, PDBe:2p6g, PDBj:2p6g
PDBsum2p6g
PubMed17513302
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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