Structure of PDB 2p6f Chain B

Receptor sequence
>2p6fB (length=436) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKAKKLENLLKLLQLNNDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDIS
DKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEF
FNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEIN
FLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRY
THRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDI
DQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQP
DGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKA
TKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGF
LNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
3D structure
PDB2p6f Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N150 F151 L152 T186 L436
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA B H38 K39 F40 W41 Y103 I168 N169 L171 C172 R178 S179 R181 L182 T183 I187 T191 V194 W200 A202 Y204 I208 L210 F425 H19 K20 F21 W22 Y84 I149 N150 L152 C153 R159 S160 R162 L163 T164 I168 T172 V175 W181 A183 Y185 I189 L191 F406
BS02 GN8 B F111 D233 F234 F92 D214 F215
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p6f, PDBe:2p6f, PDBj:2p6f
PDBsum2p6f
PubMed17513302
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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