Structure of PDB 2p53 Chain B

Receptor sequence
>2p53B (length=382) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MYALTQGRIFTGHEFLDDHAVVIADGLIKSVCPVAELPPEIEQRSLNGAI
LSPGFIDVQLNGCGGVQFNDTAEAVSVETLEIMQKANEKSGCTNYLPTLI
TTSDELMKQGVRVMREYLAKHPNQALGLHLEGPWLNLVKKGTHNPNFVRK
PDAALVDFLCENADVITKVTLAPEMVPAEVISKLANAGIVVSAGHSNATL
KEAKAGFRAGITFATHLYNAMPYITGREPGLAGAILDEADIYCGIIADGL
HVDYANIRNAKRLKGDKLCLVTNATAPAGANIEQFIFAGKTIYYRNGLCV
DENGTLSGSSLTMIEGVRNLVEHCGIALDEVLRMATLYPARAIGVEKRLG
TLAAGKVANLTAFTPDFKITKTIVNGNEVVTQ
3D structure
PDB2p53 Structural Diversity within the Mononuclear and Binuclear Active Sites of N-Acetyl-d-glucosamine-6-phosphate Deacetylase.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E131 H195 H216 E131 H195 H216
BS02 NNG B N61 E131 G141 T142 H143 H195 H216 N219 A220 H251 N273 F287 L306 G308 N61 E131 G141 T142 H143 H195 H216 N219 A220 H251 N273 F287 L306 G308 PDBbind-CN: -logKd/Ki=7.46,Ki=35nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity
Biological Process
GO:0006040 amino sugar metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006046 N-acetylglucosamine catabolic process
GO:0019262 N-acetylneuraminate catabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0032991 protein-containing complex

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Cellular Component
External links
PDB RCSB:2p53, PDBe:2p53, PDBj:2p53
PDBsum2p53
PubMed17567048
UniProtP0AF18|NAGA_ECOLI N-acetylglucosamine-6-phosphate deacetylase (Gene Name=nagA)

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