Structure of PDB 2p4y Chain B

Receptor sequence
>2p4yB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLRALAKHLYDSYIKSFPLTKAKARAILSPFVIYDMNSAIRIFQGCQFR
SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDG
VLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFI
AVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK
MTDLRQIVTEHVQLLHPLLQEIYKDLY
3D structure
PDB2p4y The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C03 B F226 C285 R288 S289 A292 I296 M329 L330 V339 I341 S342 M348 L353 M364 F18 C47 R50 S51 A54 I58 M91 L92 V101 I103 S104 M110 L115 M126 MOAD: Ki=0.001uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p4y, PDBe:2p4y, PDBj:2p4y
PDBsum2p4y
PubMed17940191
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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