Structure of PDB 2p3t Chain B

Receptor sequence
>2p3tB (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRM
NVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVD
RNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGI
VSWGEGCARKGKYGIYTKVTAFLKWIDRSMK
3D structure
PDB2p3t Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors.
ChainB
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D86 Q180 G181 D182 S183 G184
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D70 N72 Q75 E76 E80 D56 N58 Q61 E62 E64
BS02 993 B T98 Y99 E146 F174 A190 Q192 V213 W215 G216 G218 C220 G226 I227 Y228 T82 Y83 E133 F160 A178 Q180 V201 W203 G204 G206 C207 G214 I215 Y216 MOAD: Ki=0.005nM
BindingDB: Ki=0.005nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2p3t, PDBe:2p3t, PDBj:2p3t
PDBsum2p3t
PubMed17536795
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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