Structure of PDB 2p2a Chain B

Receptor sequence
>2p2aB (length=255) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYEC
3D structure
PDB2p2a A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
ChainB
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MP9 B S11 Y13 Y58 P86 L87 T88 R93 G138 S139 T140 E190 T192 M193 Y217 S11 Y13 Y58 P86 L87 T88 R93 G138 S139 T140 E190 T192 M193 Y217 MOAD: Ki=0.75uM
PDBbind-CN: -logKd/Ki=6.12,Ki=0.75uM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2p2a, PDBe:2p2a, PDBj:2p2a
PDBsum2p2a
PubMed17455929
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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