Structure of PDB 2p0r Chain B

Receptor sequence
>2p0rB (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
ARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWK
RPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIP
QDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEF
WSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYE
ILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRG
QRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFW
MAFKDFKAHFDKVEICNLT
3D structure
PDB2p0r Structures of Human Minicalpains bound to Inhibitors
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q91 C97 H254 N278 W280
Catalytic site (residue number reindexed from 1) Q73 C79 H236 N260 W262
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G95 C97 K188 G189 G190 F233 G253 G77 C79 K170 G171 G172 F215 G235
BS02 CA B E284 D291 L312 D314 E316 E266 D273 L294 D296 E298
BS03 CA B L81 G83 D88 E167 L63 G65 D70 E149
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2p0r, PDBe:2p0r, PDBj:2p0r
PDBsum2p0r
PubMed
UniProtO14815|CAN9_HUMAN Calpain-9 (Gene Name=CAPN9)

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