Structure of PDB 2p0c Chain B

Receptor sequence
>2p0cB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
NKLEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAVKTMEFLSEA
ACMKDFSHPNVIRLLGVCIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI
PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLP
VKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL
LHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
3D structure
PDB2p0c Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N728 D741 N133 D146
BS02 MG B E712 N716 E117 N121
BS03 ANP B V601 A617 F673 M674 R727 D741 V24 A40 F78 M79 R132 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2p0c, PDBe:2p0c, PDBj:2p0c
PDBsum2p0c
PubMed19028587
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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