Structure of PDB 2oz5 Chain B

Receptor sequence
>2oz5B (length=261) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVA
DLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLT
NSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKD
RTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTEL
APEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQA
TVNRMRGVLLG
3D structure
PDB2oz5 Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7XY B R59 E60 P81 H94 F98 Y125 F133 C160 A162 K164 D165 R166 V231 L232 R56 E57 P78 H91 F95 Y110 F118 C145 A147 K149 D150 R151 V216 L217 MOAD: Ki=0.33uM
BindingDB: IC50=440nM
BS02 7XY B R59 E60 R63 F98 F161 M206 R210 R56 E57 R60 F95 F146 M191 R195 MOAD: Ki=0.33uM
BindingDB: IC50=440nM
Gene Ontology
Molecular Function
GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
Biological Process
GO:0016311 dephosphorylation
GO:0051701 biological process involved in interaction with host
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oz5, PDBe:2oz5, PDBj:2oz5
PDBsum2oz5
PubMed17437721
UniProtP96830

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