Structure of PDB 2oy0 Chain B

Receptor sequence
>2oy0B (length=262) Species: 11082 (West Nile virus) [Search protein sequence]
RTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARKEGNVTGGHPV
SRGTAKLRWLVERRFLEPVGKVIDLGCGRGGWCYYMATQKRVQEVRGYTK
GGPGHEEPQLVQSYGWNIVTMKSGVDVFYRPSECCDTLLCDIGESSSSAE
VEEHRTIRVLEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGG
LVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRMEKRTWKGPQYE
EDVNLGSGTRAV
3D structure
PDB2oy0 Structure and Function of Flavivirus NS5 Methyltransferase.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B S56 G81 C82 G83 G86 W87 T104 K105 E111 D131 V132 F133 D146 I147 S51 G76 C77 G78 G81 W82 T99 K100 E106 D126 V127 F128 D141 I142
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2oy0, PDBe:2oy0, PDBj:2oy0
PDBsum2oy0
PubMed17267492
UniProtQ9Q6P4|POLG_WNV9 Genome polyprotein (Gene Name=GP1)

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