Structure of PDB 2oxe Chain B

Receptor sequence
>2oxeB (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
KEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNF
QLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEK
VNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHV
IGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVF
VDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCGIGGFVSCNHL
RSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQF
KGKTSAVEQTFFLNTGESGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSN
ENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLWNKSEPKLGASQ
ITVQSGEDGTEYNFCSSDTVEENVLQSLYPC
3D structure
PDB2oxe Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F96 S171 L172 D195 H282
Catalytic site (residue number reindexed from 1) F79 S154 L155 D178 H249
Enzyme Commision number 3.1.1.26: galactolipase.
3.1.1.3: triacylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B N383 N385 N350 N352
BS02 CA B E206 R209 D211 D214 E189 R192 D194 D197
Gene Ontology
Molecular Function
GO:0004620 phospholipase activity
GO:0004806 triacylglycerol lipase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047372 monoacylglycerol lipase activity
GO:0047714 galactolipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0009395 phospholipid catabolic process
GO:0016042 lipid catabolic process
GO:0019376 galactolipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0044241 lipid digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0042589 zymogen granule membrane
GO:0042995 cell projection
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oxe, PDBe:2oxe, PDBj:2oxe
PDBsum2oxe
PubMed18702514
UniProtP54317|LIPR2_HUMAN Pancreatic lipase-related protein 2 (Gene Name=PNLIPRP2)

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