Structure of PDB 2ovz Chain B

Receptor sequence

>2ovzB (length=155) Species: 9606 (Homo sapiens)

LKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRD
ADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLG
KGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNG
IRHLY

3D structure

• PDB: 2ovz Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity.
• Chain: B
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H401 Q402 H405 H411
• Catalytic site (residue number reindexed from 1): H113 Q114 H117 H123
• Enzyme Commision number: 3.4.24.35: gelatinase B.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H401 H405 H411	H113 H117 H123
BS02	ZN	B	H175 D177 H190 H203	H62 D64 H77 H90
BS03	CA	B	D182 G183 D185 L187 D205 E208	D69 G70 D72 L74 D92 E95
BS04	CA	B	D165 G197 Q199 G200 D201	D52 G84 Q86 G87 D88
BS05	CA	B	D131 D206 E208	D18 D93 E95
BS06	CA	B	S211 L212 G213 K214 G215	S98 L99 G100 K101 G102
BS07	CA	B	S149 T152	S36 T39
BS08	5MR	B	G186 L187 L188 A189 H190 V398 H401 Q402 H405 H411 L418 Y420 P421 M422 Y423	G73 L74 L75 A76 H77 V110 H113 Q114 H117 H123 L130 Y132 P133 M134 Y135

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0031012 extracellular matrix

External links

• PDB: RCSB:2ovz, PDBe:2ovz, PDBj:2ovz
• PDBsum: 2ovz
• PubMed: 17599356
• UniProt: P14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)