Structure of PDB 2oui Chain B

Receptor sequence
>2ouiB (length=360) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
MKGLAMLGIGRIGWIEKKIPECGPLDALVRPLALAPCTSDTHTVWAGAIG
DRHDMILGHEAVGQIVKVGSLVKRLKVGDKVIVPAITPDWGEEESQRGYP
MHSGGMLGGWKFSNFKDGVFSEVFHVNEADANLALLPRDIKPEDAVMLSD
MVTTGFHGAELANIKLGDTVCVIGIGPVGLMSVAGANHLGAGRIFAVGSR
KHCCDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVVIAGGDVHTFA
QAVKMIKPGSDIGNVNYLGEGDNIPIPRSEWGVGMGHKHIHGGLTPGGRV
RMEKLASLISTGKLDTSKLITHRFEGLEKVEDALMLMKNKPADLIKPVVR
IHYDDEDTLH
3D structure
PDB2oui Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.
ChainB
Resolution1.77 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C37 T38 S39 H42 H59 E60 D89 E92 S95 S103 D150 T154 K346
Catalytic site (residue number reindexed from 1) C37 T38 S39 H42 H59 E60 D89 E92 S95 S103 D150 T154 K346
Enzyme Commision number 1.1.1.80: isopropanol dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C37 H59 D150 C37 H59 D150
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050009 isopropanol dehydrogenase (NADP+) activity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2oui, PDBe:2oui, PDBj:2oui
PDBsum2oui
PubMed18260103
UniProtP35630|ADH1_ENTH1 NADP-dependent isopropanol dehydrogenase (Gene Name=ADH1)

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