Structure of PDB 2ot7 Chain B

Receptor sequence
>2ot7B (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPR
ASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKY
CTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTI
LDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPK
SWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIP
FDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLC
SCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
3D structure
PDB2ot7 Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
ChainB
Resolution2.135 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1) G164 Y171 H182 E184 H270 S282
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y85 N86 I87 Q88 D135 E169 G170 Y175 Y177 H240 K241 M242 T289 N290 D311 V313 Y79 N80 I81 Q82 D129 E163 G164 Y169 Y171 H234 K235 M236 T283 N284 D305 V307
BS02 ZN B C234 H240 C306 C228 H234 C300
External links
PDB RCSB:2ot7, PDBe:2ot7, PDBj:2ot7
PDBsum2ot7
PubMed17589501
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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